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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 428834Generated: October 25, 2026

1,1'-(Diazomethylene)bis(benzene) → Diphenylmethyl [4-cyano-2,3-bis-[(2-methoxy-ethoxy)-methoxy]-phenyl]-bromoacetate

https://huagongshe.com/reaction/428834

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1,1'-(Diazomethylene)bis(benzene)HCID 61230—
Reactant[4-Cyano-2,3-bis-[(2-methoxy-ethoxy)-methoxy]-phenyl]bromoacetic acidHCID 18359186—
SolventDichloromethaneHCID 6344—
ProductDiphenylmethyl [4-cyano-2,3-bis-[(2-methoxy-ethoxy)-methoxy]-phenyl]-bromoacetateHCID 53964381—

Reaction Steps

The product of Step A was dissolved in 10 ml of methylene chloride and 470 mg of diphenyl diazomethane were added. Evaporation was carried out followed by chromatography on silica (eluant: cyclohexane—ethyl acetate (2-1)) to obtain 450 mg of the desired product.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06313305B1
Source datasetuspto-grants-2001_11
ORD IDord-f13e68d288344adf8d4f6f381300c206
Source noteuspto-grants-2001_11