Acetyl chloride → HCID 22141306, compound

Participants

Reaction Conditions

Reaction Steps

A solution of [6-(3-aminophenyl)-3-hexyl-3-azabicyclo[3.1.0]hex-6-yl]methanol (Preparation 94, 0.03 g, 0.09 nmnol) in tetrahydrofuran (2 ml), stirred under nitrogen and cooled to 0° C., was treated with triethylamine (0.03 ml, 0.19 mmol) and acetyl chloride (0.01 ml, 0.17 mmol). The reaction mixture was stirred at room temperature for 3 h, saturated aqueous sodium hydrogen carbonate (50 ml) was added and the product was extracted with ethyl acetate (25 ml×3). The combined organic extracts were dried (Na2SO4) and then concentrated in vacuo. The crude residue was purified on a Sep-Pak™ cartridge packed with silica gel (5 g) to give the product as a clear glass, (11 mg, 34%).

Provenance & Evidence