Benzenesulfonic Acid → HCID 22141137, compound

Participants

Reaction Conditions

Reaction Steps

A solution of N-(3-{6-methyl-3-(3-phenylpropyl)-3-azabicyclo[3.1.0]hex-6-yl}phenyl)methanesulfonamide (Example 1, 53.88 g, 0.14 mol) in 2-butanone (480 ml) was heated under reflux. To the solution was added a solution of benzenesulfonic acid (22.17 g, 0.14 mol) in 2-butanone (50 ml) and the reaction mixture was heated under reflux for 30 min before cooling to 10° C. over a 2 h period. The resulting precipitate was collected by filtration to afford the title compound as a beige crystalline solid (73.55 g, 97%).

Provenance & Evidence