Aluminium lithium hydride → HCID 22141153, compound

Participants

Reaction Conditions

Reaction Steps

To dry tetrahydrofuran (300 ml) under nitrogen was added dropwise lithium aluminium hydride (1M in tetrahydrofuran, 75 ml, 75 mmol). To this solution, 3-allyl-6-(3-aminophenyl)-6-methyl-3-azabicyclo[3.1.0]hexan-2-one (Preparation 51, 9.0 g, 37.1 mmol) dissolved in tetrahydrofuran (200 ml), was added dropwise at 0° C. The reaction mixture was stirred for 1 h and then heated to 50° C. for 3 h. The reaction mixture was quenched with water (150 ml) and solid sodium hydrogen carbonate was added. The slurry was extracted with ethyl acetate and then dichloromethane. The organic extracts were combined and dried (Na2SO4) and then concentrated in vacuo to give the title compound as a thick yellow oil (8.5 g, 100%).

Provenance & Evidence