反应详情

To a solution of 3-mesyloxy-2-methoxy-1-hexen-5-yne (0.5 g) in acetone (1.5 ml) was added 20% sulfuric acid (1.5 ml) under ice-cooling and the mixture was stirred for 1.5 hours under the same conditions and then for 1.5 hours at room temperature. Acetone was evaporated in vacuo and the residue was extracted with methylene chloride. The extract was washed successively with water, aqueous sodium bicarbonate solution, and brine, dried over magnesium sulfate, and evaporated in vacuo to give 3-mesyloxy-5-hexyn-2-one (0.41 g).

1. temperaturecooling
2. waitfor 1.5 hours at room temperature
3. customAcetone was evaporated in vacuo
4. extractionthe residue was extracted with methylene chloride
5. washThe extract was washed successively with water, aqueous sodium bicarbonate solution, and brine
6. dry with materialdried over magnesium sulfate
7. customevaporated in vacuo