Hydrochloric Acid → HCID 18354313, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 5-fluoro-1-indanone (1.5 g, 10.0 mmol) in dimethylformamide (16 mL) and water (1.0 mL) containing potassium cyanide (855 mg., 13 mmol) and ammonium carbonate(3.19 g, 30 mmol) was sealed in a screw-top glass tubular vessel and heated at 130° C. for 24 hours. The cooled reaction vessel was opened and the contents poured into water and acidified with concentrated HCl. The resulting precipitate was collected by filtration, rinsed with water and dried. This solid was digested in ethyl acetate to give purified product as a racemate. m.p.: >260° C.

Provenance & Evidence