HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-bromobutanimide → 5-Bromo-2-oxindole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-bromobutanimide | HCID 67184 | — |
| Reactant | Oxindole | HCID 321710 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 5-Bromo-2-oxindole | HCID 611193 | 91.8% |
Reaction Steps
2-Oxindole (1.3 g) in 20 mL acetonitrile was cooled to −10° C. and 2.0 g N-bromosuccinimide was slowly added with stirring. The reaction was stirred for 1 hour at −10° C. and 2 hours at 0° C. The precipitate was collected, washed with water and dried to give 1.9 g (90% yield) of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06316429B1 |
| Source dataset | uspto-grants-2001_11 |
| ORD ID | ord-c2a18cb383414ad09d6b2bfaaeaa32d0 |
| Source note | uspto-grants-2001_11 |