HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → 4-[[(2,3-Dihydro-2-oxo-1H-indol-5-yl)amino]carbonyl]benzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 5-(4-Methoxycarbonylbenzamido)-2-oxindole | HCID 23289962 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 4-[[(2,3-Dihydro-2-oxo-1H-indol-5-yl)amino]carbonyl]benzoic acid | HCID 23289958 | 87.3% |
Reaction Steps
5-(4-Methoxycarbonylbenzamido)-2-oxindole (0.9 g) and 0.4 g of sodium hydroxide in 25 mL of methanol were refluxed for 3 hours. The mixture was concentrated, water added, and the mixture acidified with 6N hydrochloric acid. The precipitate was collected by vacuum filtration to give 0.75 g (87%) of the title compound as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06316429B1 |
| Source dataset | uspto-grants-2001_11 |
| ORD ID | ord-a1a0d28db3d9428c92d6ebe65a55c5bb |
| Source note | uspto-grants-2001_11 |