反应详情

3′-Methoxy-3-nitrobiphenyl-4-acetic acid (5.2 g) was dissolved in methanol and hydrogenated over 0.8 g of 10% palladium on carbon for 3 hours at room temperature. The catalyst was removed by filtration, washed with methanol and the filtrates combined and concentrated to give a brown solid. The solid was chromatographed on silica gel in ethyl acetate:hexane:acetic acid (33:66:1) to give 3.0 g of 6-(3-methoxypheny)-2-oxindole as a pink solid.

1. customThe catalyst was removed by filtration
2. washwashed with methanol
3. concentrationconcentrated
4. customto give a brown solid
5. customThe solid was chromatographed on silica gel in ethyl acetate:hexane:acetic acid (33:66:1)