Ammonia → HCID 18354614, compound

HRID 429162Notes

Reaction equation

HRID 429162 reaction equation
[C:1]([C:5]1[O:6][C:7]2[C:8](=[C:10]([C:14]([O:16]C)=O)[CH:11]=[CH:12][CH:13]=2)[N:9]=1)([CH3:4])([CH3:3])[CH3:2].[NH3:18]>CO>[C:1]([C:5]1[O:6][C:7]2[C:8](=[C:10]([C:14]([NH2:18])=[O:16])[CH:11]=[CH:12][CH:13]=2)[N:9]=1)([CH3:4])([CH3:3])[CH3:2]

Participants

4

Reactant 2

HCID 222AmmoniaHCID 14616763HCID 14616763, compound

Product 1

HCID 18354614HCID 18354614, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
40 °C

Procedure

Methyl 2-t-butyl-4-benzoxazole carboxylate (0.1 g; 0.46 mmol) was dissolved in methanol (5 ml), and to this was added aqueous ammonia (5 ml). The mixture was warmed to 40° C. and left to stir for 6 hours at ambient temperature. Once the reaction was complete the solvent was removed under reduced pressure and the product was recrystallised from boiling ethyl acetate and petrol (73%).

Workup

  1. waitleft
  2. customwas removed under reduced pressure
  3. customthe product was recrystallised

Sources & evidence

ORD record
ord-f5cd0942d6a543c089e4f257caca4936
Source dataset
uspto-grants-2001_11
Patent number
US06316455B1

Reaction notes

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