反应详情

3-Hydroxypicolinic acid (12.5 g, 900 mmol) was suspended in a mixture of ethanol (300 ml) and benzene (100 ml). Sulfuric acid (5 ml) was added and the reaction mixture was heated at reflux with azeotropic removal of water via Dean Stark trap. After the reaction was complete, the organics were removed in vacuo. The residue was dissolved in water, basified with sodium carbonate and extracted with ethyl acetate. The ethyl acetate layer was dried over magnesium sulfate, concentrated in vacuo to give ethyl 3-hydroxypicolinate (15 g).

1. temperaturethe reaction mixture was heated
2. customthe organics were removed in vacuo
3. dissolutionThe residue was dissolved in water
4. extractionextracted with ethyl acetate
5. dry with materialThe ethyl acetate layer was dried over magnesium sulfate
6. concentrationconcentrated in vacuo