5-Phenyl-1,3-oxazole-4-carboxylic acid → 5-Phenyl-oxazole-4-carboxylic acid [2-(2-acetyl-thiazol-4-ylmethyl)-2H-[1,2,3]triazol-4-yl]-amide

HRID 42921Notes

Reaction equation

HRID 42921 reaction equation
[CH3:1][C:2]1([C:7]2[S:8][CH:9]=[C:10]([CH2:12][N:13]3[N:17]=[C:16]([NH2:18])[CH:15]=[N:14]3)[N:11]=2)[O:6]CCO1.[C:19]1([C:25]2[O:29][CH:28]=[N:27][C:26]=2[C:30](O)=[O:31])[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1>>[C:2]([C:7]1[S:8][CH:9]=[C:10]([CH2:12][N:13]2[N:17]=[C:16]([NH:18][C:30]([C:26]3[N:27]=[CH:28][O:29][C:25]=3[C:19]3[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=3)=[O:31])[CH:15]=[N:14]2)[N:11]=1)(=[O:6])[CH3:1]

Participants

3

Reactant 2

HCID 27762995-Phenyl-1,3-oxazole-4-carboxylic acidHCID 673667592-[2-(2-Methyl-[1,3]dioxolan-2-yl)-thiazol-4-ylmethyl]-2H-[1,2,3]triazol-4-ylamine

Product 1

HCID 426467815-Phenyl-oxazole-4-carboxylic acid [2-(2-acetyl-thiazol-4-ylmethyl)-2H-[1,2,3]triazol-4-yl]-amide

Procedure

Following general procedure A followed by B, starting from 2-[2-(2-methyl-[1,3]dioxolan-2-yl)-thiazol-4-ylmethyl]-2H-[1,2,3]triazol-4-ylamine and 5-phenyl-oxazole-4-carboxylic acid.

Sources & evidence

ORD record
ord-c7a58cec40e84622ad7ba8dd5c41e797
Source dataset
uspto-grants-2013_09
Patent number
US08536209B2

Reaction notes

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