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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 429227Generated: October 30, 2026

(2R,5R)-2,5-dimethylpyrrolidine hydrochloride → 4'-{3-[(2R,5R)-2,5-dimethylpyrrolidinyl]propoxy}-N-isopropyl[1,1'-biphenyl]-4-carboxamide

https://huagongshe.com/reaction/429227

Reaction equation

Participants

RoleNameHCIDCharge
Reactant(2R,5R)-2,5-dimethylpyrrolidine hydrochlorideHCID 12268509—
Reactant4'-(3-chloropropoxy)-N-isopropyl[1,1'-biphenyl]-4-carboxamideHCID 18354763—
Product4'-{3-[(2R,5R)-2,5-dimethylpyrrolidinyl]propoxy}-N-isopropyl[1,1'-biphenyl]-4-carboxamideHCID 70139218—

Reaction Steps

The product from Example 1A and (2R,5R)-2,5-dimethylpyrrolidine hydrochloride were processed as described in Example 10F to provide the title compound.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06316475B1
Source datasetuspto-grants-2001_11
ORD IDord-55f3176336e84fa2b6511fa176fe6771
Source noteuspto-grants-2001_11