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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 429242Generated: October 25, 2026

rel-(2R,6S)-2,6-Dimethylpiperidine → (2R,6S)-2,6-dimethyl-1-(3-{[4'-(1-pyrrolidinylcarbonyl)[1,1'-biphenyl]-4-yl]oxy}propyl)piperidine

https://huagongshe.com/reaction/429242

Reaction equation

Participants

RoleNameHCIDCharge
Reactantrel-(2R,6S)-2,6-DimethylpiperidineHCID 641768—
Reactant[4'-(3-Chloropropoxy)[1,1'-biphenyl]-4-yl](pyrrolidin-1-yl)methanoneHCID 22994486—
Product(2R,6S)-2,6-dimethyl-1-(3-{[4'-(1-pyrrolidinylcarbonyl)[1,1'-biphenyl]-4-yl]oxy}propyl)piperidineHCID 70141065—

Reaction Steps

The product from Example 11A and (2R,6S)-2,6-dimethylpiperidine were processed as described in Example 10F to provide the title compound.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06316475B1
Source datasetuspto-grants-2001_11
ORD IDord-5776e4694b23475da398be011cde973e
Source noteuspto-grants-2001_11