3-Hydroxypiperidine, (R)- → HCID 70141086, compound

HRID 429243Notes

Reaction equation

HRID 429243 reaction equation
Cl[CH2:2][CH2:3][CH2:4][O:5][C:6]1[CH:11]=[CH:10][C:9]([C:12]2[CH:17]=[CH:16][C:15]([C:18]([N:20]3[CH2:24][CH2:23][CH2:22][CH2:21]3)=[O:19])=[CH:14][CH:13]=2)=[CH:8][CH:7]=1.[NH:25]1[CH2:30][CH2:29][CH2:28][C@@H:27]([OH:31])[CH2:26]1>>[N:20]1([C:18]([C:15]2[CH:16]=[CH:17][C:12]([C:9]3[CH:10]=[CH:11][C:6]([O:5][CH2:4][CH2:3][CH2:2][N:25]4[CH2:30][CH2:29][CH2:28][C@@H:27]([OH:31])[CH2:26]4)=[CH:7][CH:8]=3)=[CH:13][CH:14]=2)=[O:19])[CH2:24][CH2:23][CH2:22][CH2:21]1

Participants

3

Reactant 2

HCID 27593343-Hydroxypiperidine, (R)-HCID 22994486[4'-(3-Chloropropoxy)[1,1'-biphenyl]-4-yl](pyrrolidin-1-yl)methanone

Product 1

HCID 70141086HCID 70141086, compound

Procedure

The product from Example 11A and (3R)-3-piperidinol were processed as described in Example 10F to provide the title compound.

Sources & evidence

ORD record
ord-1952bd8667a845179e2d60779d5ff4f7
Source dataset
uspto-grants-2001_11
Patent number
US06316475B1

Reaction notes

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