Hydrochloric Acid → HCID 20703634, compound

Participants

Reaction Steps

To a solution of 2-[1-(1-methylpiperazine-2-yl)-ethylamino]-4-[benzimidazol-1-yl]-pyrimidine (EXAMPLE 20; 3 mg) in 4 mL of DMSO was added benzyl bromide (2 μL) and K2CO3 (2.2 mg). The mixture was stirred for 2d at room temperature, then diluted with 5 mL of EtOAc and poured into 10 mL of 1N HCl. The phases were separated and the aqueous phase was basified (pH>11) with 5N NaOH and extracted with 4×5 mL of EtOAc. The combined organics were dried over Na2SO4 and concentrated. The residue was purified by preparative thin-layer chromatography, eluting with 95:5 CH2Cl2—MeOH to provide 1.9 mg of the title compound. Mass spectrum (ESI) 428.4 (M+1).

Provenance & Evidence