HuagongsheHuagongshe Chemistry Print Report · For research reference only
Indole → 2-Methylthio-4-[indol-1-yl]pyrimidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Indole | HCID 798 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 4-Chloro-2-methylthiopyrimidine | HCID 97113 | — |
| Reactant | 2-[Indol-1-yl]-4-methylthiopyrimidine | HCID 18354384 | — |
| Reactant | Potassium hydroxy sulfite | HCID 23707502 | — |
| Product | 2-Methylthio-4-[indol-1-yl]pyrimidine | HCID 18354362 | — |
| Product | HCID 18354396 | HCID 18354396 | — |
Reaction Steps
2-Methylthio-4-[indol-1-yl]pyrimidine was prepared from indole (1.00 g), NaH (220 mg), and 4-chloro-2-methylthiopyrimidine (0.9 mL) according to the procedure described in EXAMPLE 1, Step A. The title compound was prepared from 2-[indol-1-yl]-4-methylthiopyrimidine (2.11 g) and oxone (10.5 g) according to the procedure described in EXAMPLE 1, Step B. Mass spectrum (ESI) 274.0 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06316444B1 |
| Source dataset | uspto-grants-2001_11 |
| ORD ID | ord-4e0967b7e9c0493ea9a859cd78396d5e |
| Source note | uspto-grants-2001_11 |