1-Benzyloxycarbonyl-2-(1-aminoethyl)-4-tert-butyloxycarbonylpiperazine → HCID 18354378, compound

HRID 429301Notes

Reaction equation

HRID 429301 reaction equation
CS([C:5]1[N:10]=[C:9]([N:11]2[C:15]3[CH:16]=[CH:17][C:18]([N:20]4[CH2:24][CH2:23][N:22]([CH2:25][CH3:26])[C:21]4=[O:27])=[CH:19][C:14]=3[N:13]=[CH:12]2)[CH:8]=[CH:7][N:6]=1)(=O)=O.[CH2:28]([O:35][C:36]([N:38]1[CH2:43][CH2:42][N:41]([C:44]([O:46][C:47]([CH3:50])([CH3:49])[CH3:48])=[O:45])[CH2:40][CH:39]1[CH:51]([NH2:53])[CH3:52])=[O:37])[C:29]1[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=1>>[CH2:28]([O:35][C:36]([N:38]1[CH2:43][CH2:42][N:41]([C:44]([O:46][C:47]([CH3:48])([CH3:49])[CH3:50])=[O:45])[CH2:40][CH:39]1[CH:51]([NH:53][C:5]1[N:10]=[C:9]([N:11]2[C:15]3[CH:16]=[CH:17][C:18]([N:20]4[CH2:24][CH2:23][N:22]([CH2:25][CH3:26])[C:21]4=[O:27])=[CH:19][C:14]=3[N:13]=[CH:12]2)[CH:8]=[CH:7][N:6]=1)[CH3:52])=[O:37])[C:29]1[CH:30]=[CH:31][CH:32]=[CH:33][CH:34]=1

Participants

3

Reactant 2

HCID 183428831-Benzyloxycarbonyl-2-(1-aminoethyl)-4-tert-butyloxycarbonylpiperazineHCID 18354395HCID 18354395, compound

Product 1

HCID 18354378HCID 18354378, compound

Procedure

The title compound was prepared from 2-methanesulfonyl-4-[5-(3-ethyl-imidazolidin-2-on-1-yl)benzimidazol-1-yl]pyrimidine (EXAMPLE 29; 95 mg) and 1-benzyloxycarbonyl-2-(1-aminoethyl)-4-tert-butyloxycarbonylpiperazine, diastereomer 1 (EXAMPLE 14 Step D; 100 mg) according to the procedure described in EXAMPLE 14, Step E. Mass spectrum (ESI) 670.5 (M+1).

Sources & evidence

ORD record
ord-4261e2fa99f94c0f94e1ab66d8823618
Source dataset
uspto-grants-2001_11
Patent number
US06316444B1

Reaction notes

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