HuagongsheHuagongshe Chemistry Print Report · For research reference only
Formaldehyde → 2-[1-(1-Methyl-4-(N-naphth-1-yi-carbamoyl)-piperazine-2-yl)-ethylamino]-4-[5-(3-ethyl-imidazolidin-2-on-1-yl)benzimidazol-1-yl]pyrimidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Formaldehyde | HCID 712 | — |
| Reactant | Sodium cyanoborohydride | HCID 5003444 | — |
| Reactant | 2-[1-(1-(benzyloxycarbonyl)-4-(N-naphth-1-yl-carbamoyl)-piperazine-2-yl)-ethylamino]-4-[5-(3-ethyl-imidazolidin-2-on-1-yl)benzimidazol-1-yl]pyrimidine | HCID 18354373 | — |
| Product | 2-[1-(1-Methyl-4-(N-naphth-1-yi-carbamoyl)-piperazine-2-yl)-ethylamino]-4-[5-(3-ethyl-imidazolidin-2-on-1-yl)benzimidazol-1-yl]pyrimidine | HCID 18354355 | — |
Reaction Steps
The title compound was prepared from 2-[1-(1-(benzyloxycarbonyl)-4-(N-naphth-1-yl-carbamoyl)-piperazine-2-yl)-ethylamino]-4-[5-(3-ethyl-imidazolidin-2-on-1-yl)benzimidazol-1-yl]pyrimidine (28 mg), 37% aqueous formaldehyde (19 μL), and NaBH3CN (4.8 mg) according to the procedure described in EXAMPLE 14, Step G. Mass spectrum (ESI) 619.3 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06316444B1 |
| Source dataset | uspto-grants-2001_11 |
| ORD ID | ord-37412047e89444ccabb1b0e676a80128 |
| Source note | uspto-grants-2001_11 |