4-Bromopyridine → HCID 18354346, compound

Participants

Reaction Conditions

Reaction Steps

2-Methylthio-4-[5-trimethylstannyl-benzimidazol-1-yl]pyrimidine (150 mg), 4-bromopyridine (180 mg), tri-o-tolylphosphine (5 mg) and tris(dibenzylidineacetone)dipalladium(0) (7.5 mg) were dissolved in DMF (3 mL) and heated to 100° C. for 1 hour. Upon cooling to rn and evaporation of solvent, the reaction residue was directly purified by column chromatography (SiO2,5% MeOH in CH2Cl2) to yield 100 mg of the title compound. Mass spectrum (ESI) 320.2 (M+1).

Provenance & Evidence