alpha-Naphthyl isocyanate → HCID 70213489, compound

HRID 429306Notes

Reaction equation

[CH2:1]([O:8][C:9]([N:11]1[CH2:16][CH2:15][N:14](C(OC(C)(C)C)=O)[CH2:13][C@H:12]1[C@@H:24]([NH:26][C:27]1[N:32]=[C:31]([N:33]2[C:37]3[CH:38]=[CH:39][C:40]([C:42]4[CH:47]=[CH:46][N:45]=[CH:44][CH:43]=4)=[CH:41][C:36]=3[N:35]=[CH:34]2)[CH:30]=[CH:29][N:28]=1)[CH3:25])=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:48]1([N:58]=[C:59]=[O:60])[C:57]2[C:52](=[CH:53][CH:54]=[CH:55][CH:56]=2)[CH:51]=[CH:50][CH:49]=1>>[CH2:1]([O:8][C:9]([N:11]1[CH2:16][CH2:15][N:14]([C:59](=[O:60])[NH:58][C:48]2[C:57]3[C:52](=[CH:53][CH:54]=[CH:55][CH:56]=3)[CH:51]=[CH:50][CH:49]=2)[CH2:13][C@H:12]1[C@@H:24]([NH:26][C:27]1[N:32]=[C:31]([N:33]2[C:37]3[CH:38]=[CH:39][C:40]([C:42]4[CH:43]=[CH:44][N:45]=[CH:46][CH:47]=4)=[CH:41][C:36]=3[N:35]=[CH:34]2)[CH:30]=[CH:29][N:28]=1)[CH3:25])=[O:10])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

Reactant 2

HCID 66589alpha-Naphthyl isocyanate

HCID 70213536HCID 70213536, compound

Product 1

HCID 70213489HCID 70213489, compound

Procedure

The title compound was prepared from (S,S)-2-[1-(1-(benzyloxycarbonyl)-4-(tert-butyloxycarbonyl)piperazine-2-yl)-ethylamino]-4-[5-(pyridine-4-yl)benzimidazol-1-yl]pyrimidine (72 m,) and naphthyl isocyanate (23 mg) according to the procedure described in EXAMPLE 14, Step F. Mass spectrum (ESI) 704.2 (M+1).

Sources & evidence

ORD record: ord-0a9dcaf1b6d54d599e0a117efed09d9d
Source dataset: uspto-grants-2001_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06316444B1

Reaction notes

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