Formaldehyde → HCID 18354360, compound

Participants

Reaction Steps

The title compound was prepared from (S,S)-2-[1-(1-(benzyloxycarbonyl)-4-(N-naphth-1-yl-carbamoyl)-piperazine-2-yl)-ethylamino]-4-[5-(2-amino-pyrimidin-4-yl)benzimidazol-1-yl]pyrimidine (5.5 mg), 37% aqueous formaldehyde (0.7 μL), and NaBH3CN (1 mg) according to the procedure described in EXAMPLE 14, Step G. 1H NMR (500 MHz, CDCl3): δ8.64 (s, 1H); 8.47 (d, J=1.5 Hz, 1H); 8.34-8.41 (m, 2H); 8.20 (d, J=8.5 Hz, 1H); 8.09 (dd, J=1.6, 8.5 Hz, 1H); 7.76-7.83 (m, 2H); 7.61 (t, J=7.1 Hz, 2H); 7.37-7.55 (m, 3H); 7.12 (d, J=5.5 Hz, 1H); 6.78 (d, J=5,5 Hz, 1H); 5.77 (br s, 1H); 5.13 (s, 2H); 4.50-4.60 (m, 1H); 4.09 (br d, J=12 Hz, 1H); 3.88 (br d, J=12 Hz, 1H); 3.20 (br t, J=11 Hz, 1H); 3.09 (dd, J=10, 13 Hz, 1H); 2.92 (br d, J=12 Hz, 1H) 2.40-2.60 (m, 5H); 1.36 (d, J=6.5 Hz, 3H). Mass spectrum (ESI) 431.2 (M-(N-naphthyl carbamoyl)+1).

Provenance & Evidence