Nitric Acid → HCID 18355380, compound

HRID 429315Notes

Reaction equation

HRID 429315 reaction equation
[N+:1]([O-:4])(O)=[O:2].[CH3:5][O:6][C:7]1[CH:12]=[CH:11][C:10]([N:13]2[C:17]([C:18]3[CH:23]=[CH:22][C:21]([S:24]([CH3:27])(=[O:26])=[O:25])=[CH:20][CH:19]=3)=[CH:16][C:15]([C:28]([F:31])([F:30])[F:29])=[N:14]2)=[CH:9][CH:8]=1>C(OC(=O)C)(=O)C>[CH3:5][O:6][C:7]1[CH:8]=[CH:9][C:10]([N:13]2[C:17]([C:18]3[CH:19]=[CH:20][C:21]([S:24]([CH3:27])(=[O:25])=[O:26])=[CH:22][CH:23]=3)=[CH:16][C:15]([C:28]([F:31])([F:29])[F:30])=[N:14]2)=[CH:11][C:12]=1[N+:1]([O-:4])=[O:2]

Participants

4

Reactant 2

HCID 944Nitric AcidHCID 10524779HCID 10524779, compound

Product 1

HCID 18355380HCID 18355380, compound

Reagents, catalysts & solvents 1

HCID 7918Acetic AnhydrideSolvent

Procedure

To acetic anhydride (20 ml) was added 70% nitric acid (2 ml) dropwise in an ice-bath. During the addition, the internal temperature of the mixture temporarily rose to 25° C. and dropped to 0° C. To the mixture was added 1-(4-methoxyphenyl)-5-[4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)pyrazole (2.0 g) portionwise. The reaction mixture was allowed to stir for 5 hours and poured into ice-water. The precipitate formed was collected by filtration and dried to give 1-(4-methoxy-3-nitrophenyl)-5-[4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)pyrazole (2.15 g).

Workup

  1. additionDuring the addition
  2. customtemporarily rose to 25° C.
  3. additiondropped to 0° C
  4. customThe precipitate formed
  5. filtrationwas collected by filtration
  6. customdried

Sources & evidence

ORD record
ord-ef5b3d484b1444e2aed4a132b8110cde
Source dataset
uspto-grants-2001_11
Patent number
US06316485B1

Reaction notes

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