Nitric Acid → HCID 18355378, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 3-chloro-1-(3-methoxyphenyl)-5-[4-(methylsulfonyl)phenyl]pyrazole (575 mg) in acetic anhydride (10 ml) and acetic acid (1 ml) was added nitric acid (fuming) (500 ml) at 0° C. After being stirred at 0° C. for 2 hours, the reaction mixture was poured into water, and extracted with dichloromethane. The organic layer was dried over magnesium sulfate, and filtered. The filtrate was evaporated in vacuo, and purified by column chromatography using dichloromethane as eluent to give 3-chloro-1-(3-methoxy-4-nitro-phenyl)-5-[4-(methylsulfonyl)phenyl]pyrazole (590 mg).

Provenance & Evidence