Hydrazine hydrate (1:1) → HCID 18355415, compound

Participants

Reaction Steps

To a solution of 3-chloro-1-(3-methoxy-4-nitrophenyl)-5-[4-(methylsulfonyl)phenyl]pyrazole (900 mg) in ethanol (30 ml) and tetrahydrofuran (30 ml) were added active carbon (3 g), hydrazine monohydrate (2 ml) and ferric chloride (50 mg). The mixture was refluxed for 2 hours, and filtered. The filtrate was evaporated in vacuo and partitioned between water and dichloromethane. The organic layer was dried over magnesium sulfate and filtered. The filtrate was evaporated in vacuo to give 1-(4-amino-3-methoxyphenyl)-3-chloro-5-[4-(methylsulfonyl)phenyl]pyrazole (820 mg).

Provenance & Evidence