反应详情

A mixture of 1-(3-cyano-4-methoxyphenyl)-5-[4-(methylthio)phenyl]-2-pyrazoline-3-amine (4.0 g) and manganese(IV) oxide (6.0 g) in toluene (100 ml) was stirred at ambient temperature for 8 hours. The insoluble material was filtered and washed with ethyl acetate. The resulting solution was concentrated under reduced pressure. The residue was subjected to column chromatography on silica gel eluting with a mixture of acetone and dichloromethane (1:1) to give partially purified 1-(3-cyano-4-methoxyphenyl)-5-[4-(methylthio)phenyl]pyrazole-3-amine (1.1 g).

1. filtrationThe insoluble material was filtered
2. washwashed with ethyl acetate
3. concentrationThe resulting solution was concentrated under reduced pressure
4. additionThe residue was subjected to column chromatography on silica gel eluting with a mixture of acetone and dichloromethane (1:1)