Sodium Thiosulfate → HCID 9801815, compound

Participants

Reaction Steps

To a solution of 1-(3-chloro-4-methoxyphenyl)-3-(difluoromethyl)-5-[4-(methylthio)phenyl]pyrazole (2.0 g) in dichloromethane (50 ml) was added portionwise m-chloroperbenzoic acid (2.3 g, 80% purity) at 5° C. with stirring. After being stirred at room temperature for 2 hours, the reaction mixture was treated with aqueous solution of sodium thiosulfate and then partitioned between dichloromethane and water. The organic layer was separated, washed with aqueous sodium hydrogen carbonate solution and dried over magnesium sulfate. After evaporation of the solvent, the crude solid was recrystallized from ethanol to give 1-(3-chloro-4-methoxyphenyl)-3-(difluoromethyl)-5-[4-(methylsulfonyl)phenyl]pyrazole (1.8 g).

Provenance & Evidence