Nitric Acid → HCID 9953232, compound

Participants

Reaction Steps

To a stirred solution of 3-chloro-1-(4-methoxyphenyl)-5-[4-(methylsulfonyl)phenyl]pyrazole (278 mg) in a mixture of acetic anhydride (5 ml) and acetic acid (5 ml), nitric acid (sp. gr. 1.42) (0.5 ml) was added at 0° C. After 30 minutes, the resulting mixture was poured into water and extracted with ethyl acetate. The extract was washed with brine, dried over magnesium sulfate, and concentrated under reduced pressure to give crystals. The resulting crystals were washed with ethyl acetate to give 3-chloro-1-(4-methoxy-3-nitro-phenyl)-5-[4-(methylsulfonyl)phenyl]pyrazole (297 mg).

Provenance & Evidence