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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 429341Generated: October 29, 2026

Potassium Carbonate → 4-[2-(1-Methylpyrrolidin-2-yl)ethylsulfanyl]phenol

https://huagongshe.com/reaction/429341

Reaction equation

Participants

RoleNameHCIDCharge
ReactantPotassium CarbonateHCID 11430—
Reactant4-MercaptophenolHCID 240147—
Reactant2-(2-Chloroethyl)-1-methylpyrrolidineHCID 285093—
SolventDimethylformamideHCID 6228—
Product4-[2-(1-Methylpyrrolidin-2-yl)ethylsulfanyl]phenolHCID 531096844.3%

Reaction Steps

2-(2-Chloroethyl)-1-methylpyrrolidine (2.0 g, 13.5 mmole), 4-hydroxythiophenol (1.7 g, 13.5 mmole), potassium carbonate (18.7 g, 135.4 mmole) and DMF (26 mL) were combined, yielding 1.42 g (5.98 mmole, 44%) of the desired compound.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06316490B1
Source datasetuspto-grants-2001_11
ORD IDord-dc8ff5556aad43c08ad9ff64f155ee37
Source noteuspto-grants-2001_11