Acetone → 1-Phenethylamine, (+)-

HRID 429386Notes

Reaction equation

HRID 429386 reaction equation
CC(C)=O.[C:5]1([C@@H:11]([NH2:13])[CH3:12])[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1>O>[C:5]1([C@H:11]([NH2:13])[CH3:12])[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1

Participants

4

Reactant 2

HCID 180AcetoneHCID 758181-Phenethylamine, (-)-

Product 1

HCID 6431891-Phenethylamine, (+)-Yield 234%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

The above two crystals were combined (0.89 g), 13 ml of a mixed solution of acetone:water=8:5 was added, and stirring was carried out at 55° C. 0.47 g of (S)-(−)-1-phenylethylamine was added to this solution, and it was stirred at room temperature for 15 hours. The resulting crystals were filtered, yielding 1.10 g of (R)-(−)-1-phenylethylamine salt.

Workup

  1. customwas carried out at 55° C
  2. stirringwas stirred at room temperature for 15 hours
  3. filtrationThe resulting crystals were filtered

Sources & evidence

ORD record
ord-3729fb6dee304c37ab7d5d38d6d2a231
Source dataset
uspto-grants-2001_11
Patent number
US06316498B1

Reaction notes

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