Pyridinium chloride → HCID 86754549, compound

HRID 429450Notes

Reaction equation

HRID 429450 reaction equation
C[O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[O:9][CH2:8][C@@H:7]([C:13]1[CH:18]=[CH:17][CH:16]=[C:15]([O:19]C)[CH:14]=1)[C@H:6]2[C:21]1[CH:26]=[CH:25][C:24]([O:27][CH2:28][CH2:29][N:30]2[CH2:34][CH2:33][CH2:32][CH2:31]2)=[CH:23][CH:22]=1.Cl.N1C=CC=CC=1>>[OH:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[O:9][CH2:8][C@@H:7]([C:13]1[CH:18]=[CH:17][CH:16]=[C:15]([OH:19])[CH:14]=1)[C@H:6]2[C:21]1[CH:26]=[CH:25][C:24]([O:27][CH2:28][CH2:29][N:30]2[CH2:31][CH2:32][CH2:33][CH2:34]2)=[CH:23][CH:22]=1

Participants

3

Reactant 2

HCID 10176127Pyridinium chlorideHCID 86754550HCID 86754550, compound

Product 1

HCID 86754549HCID 86754549, compound

Procedure

Thus, (±)-cis-6-methoxy-3-(3-methoxyphenyl)-4-(4-(2-pyrrolidinoethoxy)phenyl)-chromane (0.24 g, 0.52 mmol) was de-methylated by heating with pyridine hydrochloride (0.60 g, 5.20 mmol) to give the title compound, after purification and drying, as a colourless gum.

Sources & evidence

ORD record
ord-fdc41550d3e948ecb8851a63b9fd5ade
Source dataset
uspto-grants-2001_11
Patent number
US06316494B1

Reaction notes

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