HCID 131721745, compound → HCID 69961800, compound

Participants

Reaction Steps

(+,−) cis [4-(7-Benzyloxy-3-phenyl-chroman-4-yl)-phenoxy]-acetic acid methyl ester(100 mg, 0.21 mmol) was dissolved in a solvent mixture of tetrahydrofuran-methanol-formic acid (8+1+1, 10 ml). The solution was added to a 5% Palladium on carbon catalyst (20 mg), and hydrogenated (1 atm.) overnight. The reaction mixture was filtered and evaporated to give a dark oil, which was dissolved and evaporated from EtOH (×3), triturated with toluene, and recrystallised from toluene.

Provenance & Evidence