Triethylamine → 3,4-Dichlorophenylacetic acid trimethylacetyl ester

Participants

Reaction Steps

Combine 3,4-dichlorophenyl acetic acid (31.5 g, 154 mmol) and triethylamine (25.7 ml, 184 mmol) and tetrahydrofuran (300 ml). Cool in a dry-ice/acetone bath. Add trimethylacetyl chloride (18.5 grams, 154 mmol) and tetrahydrofuran (200 ml). Warm to ambient temperature to give the title compound in solution.

Provenance & Evidence