Sodium Thiosulfate → HCID 15536016, compound

Participants

Reaction Steps

Combine (S)-N-methyl-N-(2-(3,4-dichlorophenyl)pent-4-enyl)-2-methoxy-5-(1H-tetrazol-1-yl)benzamide (5.12 g, 11.5 mmol), acetone/t-butanol/water (2/1/1, 120 mL), and a solution of N-methylmorpholine N-oxide (3.3 g 50% in water). Add a solution of osmium tetraoxide (4.4 g, 4% in water, 13.8 mmol). After 2 hours, evaporate in vacuo to remove most of the acetone and partition the evaporated reaction mixture between dichloromethane and an aqueous 10% solution of sodium thiosulfate. Separate the layers, extract the organic layer with brine, dry over MgSO4, filter, and evaporate in vacuo to give a residue. Combine the residue and tetrahydrofuran/water (4/1 150 mL). Add sodium meta-periodate (2.95 g, 13.8 mmol). After 1.5 hours, filter the reaction mixture, rinse the solids with tetrahydrofuran, and evaporate the filtrate to remove most of the tetrahydrofuran. Dilute the evaporated reaction mixture with dichloromethane. Extract with water, dry over MgSO4, filter, and evaporate in vacuo to give a residue. Chromatograph the residue on silica gel eluting sequentially with 1% methanol/dichloromethane, 2% methanol/dichloromethane, and 3% methanol/dichloromethane to give the title compound: Rf=0.20 (silica gel, 6% methanol/dichloromethane).

Provenance & Evidence