反应详情

Combine methyl 2-methoxy-5-(4H-triazol-4-yl)benzoate (56 mmol) and methanol (200 mL) and water (50 mL). Add 1 M aqueous solution of sodium hydroxide (62.5 mL, 62.5 mmol). Heat to reflux. After 8 hour, concentrate in vacuo to remove most of the solvent. Adjust the pH to about 1 to 2 using a 1 M aqueous hydrochloric acid solution, extract with dichloromethane. Dry the organic layer over MgSO4, filter, and evaporate in vacuo to give 2-methoxy-5-(4H-triazol-4-yl)benzoic acid.

1. temperatureHeat to reflux
2. concentrationconcentrate in vacuo
3. customto remove most of the solvent
4. extractionextract with dichloromethane
5. dry with materialDry the organic layer over MgSO4
6. filtrationfilter
7. customevaporate in vacuo