Formaldehyde → HCID 54059009, compound

Participants

Reaction Steps

Concentrated sulfuric acid (1 mL) is slowly added to a solution of 3-(dimethylamino)-2-propenal (200 g, 2.01 mol) and paraformaldehyde (90 g, 3 mol) in methanol (1 L). The resultant solution is refluxed overnight, concentrated in vacuo to a volume of 200 mL, diluted with toluene and distilled until the vapor temperature is 105° C. The solution is then concentrated in vacuo to give the title product as an orange oil (251.4 g, 87% yield).

Provenance & Evidence