Methanol → Tartrate

Participants

Reaction Steps

Subsequently, 10.00 g (44.0 mmol) of the trans-(−)-4-(4-fluorophenyl)-3-hydroxymethylpiperidine monohydrate, 6.60 g (44.0 mmol) of L-tartaric acid, and 50 ml of methanol were mixed together, and 50 ml of isopropanol was added to the resulting mixture under ice-cooling. The mixture was allowed to stand to precipitate crystals, and the resulting crystals were filtered. The crystals were washed with a 10 ml mixed solvent of 5 ml of methanol and 5 ml of isopropanol and dried, to give 5.60 g (15.6 mmol) of L-tartrate of trans-(−)-4-(4-fluorophenyl)-3-hydroxymethylpiperidine (yield: 35.5%).

Provenance & Evidence