4-Methylphthalic anhydride → 2-Hydroxy-5-methyl-1H-isoindole-1,3(2H)-dione

Participants

Reaction Steps

500 mg (3.08 mmol) of 4-methylphthalic anhydride and 243 mg (1.23 mmol) of hydroxylammonium phosphate were mixed and heated with 1 ml of water at a bath temperature of 130° C. for 3 hours. The cooled mixture was digested with 30 ml of water. The precipitate which formed was filtered off with suction and dried at 60° C. under reduced pressure. The yield was 437 mg (80%).

Provenance & Evidence