HuagongsheHuagongshe Chemistry Print Report · For research reference only
Morpholine → 2-Oxoindoline-5-sulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Morpholine | HCID 8083 | — |
| Reactant | 2-oxo-2,3-dihydro-1H-indole-5-sulfonyl chloride | HCID 4962506 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 2-Oxoindoline-5-sulfonamide | HCID 10198232 | 99.2% |
Reaction Steps
5-Chlorosulfonyl-2-indolinone (2.3 g) and 2.2 g morpholine in 50 mL of dichloromethane was stirred for 3 hours at room temperature. The precipitate was collected by vacuum filtration, washed with ethyl acetate and hexane and dried to give 2.09 g (74%) of the title compound as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06316635B1 |
| Source dataset | uspto-grants-2001_11 |
| ORD ID | ord-4e5eb95717a4477a8f2a5a75dfad8bb5 |
| Source note | uspto-grants-2001_11 |