反应详情

To a solution of 1-benzyl-5-aminobenzimidazole (1.0 g, 5.0 mmol) in 40 ml of AcOH was added solution of Br2 in AcOH until it produces a precipitate. The reaction mixture was concentrated in vacuo to provide a brown solid which was subjected to column chromatography (5% NH3 sat'd MeOH/CHCl3) to provide 0.90 g (2.5 mmol, 60%) of the product.

1. customproduces a precipitate
2. concentrationThe reaction mixture was concentrated in vacuo
3. customto provide a brown solid which