Bromine → HCID 178432201, compound

HRID 429566Notes

Reaction equation

HRID 429566 reaction equation
[CH3:1][C:2]1[NH:3][C:4]2[CH:10]=[C:9]([NH2:11])[CH:8]=[CH:7][C:5]=2[N:6]=1.[Br:12]Br>CC(O)=O>[CH3:1][C:2]1[NH:3][C:4]2[C:10]([Br:12])=[C:9]([NH2:11])[CH:8]=[CH:7][C:5]=2[N:6]=1

Participants

4

Reactant 2

HCID 24408BromineHCID 315500NoName_3663

Product 1

HCID 178432201HCID 178432201, compoundYield 80.6%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Conditions

Temperature
25 °C

Procedure

To a solution of 0.9 g (6.1 mmol) of 2-methyl-5-aminobenzimidazole in 50 ml of AcOH was added 0.16 ml of Br2 (3.1 mmol) dropwise and resulting reaction mixture was stirred for 1 h at 25° C. Reaction mixture was concentrated in vacuo and purified on silica gel column chromatography (20% Isopropanol/EtOAC) to yield 0.56 g (2.5 mmol, 41%) of the desired product.

Workup

  1. customresulting
  2. customreaction mixture
  3. customReaction mixture
  4. concentrationwas concentrated in vacuo
  5. custompurified on silica gel column chromatography (20% Isopropanol/EtOAC)

Sources & evidence

ORD record
ord-a5e972421d32405c80f8d552a3f68e86
Source dataset
uspto-grants-2001_11
Patent number
US06316637B1

Reaction notes

Loading…