反应详情

温度

25 °C

To a solution of 0.87 g (4.9 mmol) of 2-cyclopropyl-5-aminobenzimidazole in 50 ml of AcOH was added 0.10 ml (1.9 mmol) of Br2 dropwise and resulting reaction mixture was stirred for 1 h at 25° C. The reaction mixture was concentrated in vacuo and purified on silica gel column chromatography (5% MeOH/EtOAC) to yield 0.42 g (1.8 mmol, >95%) of the desired product.

1. customresulting
2. customreaction mixture
3. concentrationThe reaction mixture was concentrated in vacuo
4. custompurified on silica gel column chromatography (5% MeOH/EtOAC)