Ammonia → HCID 178419285, compound

Participants

Reaction Steps

To a solution of 4-bromo-5-(2-imidazolin-2-ylamino)benzimidazole (0.2 g, 0.7 mmol) in 10 ml AcOH was added 200 mg of Hg(OAc)2 and few drops of Br2. Reaction mixture was concentrated in vacuo, yielding a dark oily residue, which was subjected to silica gel column chromatography (NH3 sat'd 30% MeOH/EtOAc) to provide 210 mg (0.58 mmol, 86%) of the desired product. The product obtained was converted to the fumarate salt and recrystallized from EtOH to afford 0.051 g (14%) of the product as a white solid.

Provenance & Evidence