Ammonia → HCID 18379816, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 7-chloro-5-(2-imidazolin-2-ylamino)benzimidazole (0.61 g, 2.6 mmol) in 10 ml of AcOH was added 0.3 ml of Br2. Resulting reaction mixture was stirred for 12 h at 25° C. and concentrated in vacuo, yielding an oil, which was subjected to column chromatography (NH3 sat'd 30% MeOH/EtOAc) to yield 0.23 g (0.85 mmol, 33%) of the desired product. The product obtained was converted to the fumarate salt and recrystallized from MeOH to afford 0.12 g (12%) of the product as a light yellow solid: mp 244-246° C.; Anal. Calc. for C10H9N5BrCl. 1.0C4H4O4.0.5H2O requires C, 37.77; H, 3.17; N,18.35. Found: C, 37.75; H, 3.08; N, 18.21.

Provenance & Evidence