3,3-Dimethoxybutan-2-ol → 3,3-Dimethoxy-2-butanone
Reaction equation
[CH3:1][O:2][C:3]([O:8][CH3:9])([CH3:7])[CH:4]([OH:6])[CH3:5]>CC(=O)CC>[CH3:1][O:2][C:3]([O:8][CH3:9])([CH3:7])[C:4](=[O:6])[CH3:5]Participants
Reactant 1
Product 1
Reagents, catalysts & solvents 1
Procedure
Advantageous starting materials of the formula II are also compounds in which X is 2 alkoxy groups. These can be obtained very advantageously, even industrially, by the electrochemical process described in EP 460 451 B1. Thus, for example, 3,3-dimethoxy-2-butanol, which is particularly suitable for the preparation of diacetyl, is obtained by this process from 2-butanone (methyl ethyl ketone) in a selectivity of 70% of theory (cf. Example 1A). From this, the novel process can be used to obtain 3,3-dimethoxy-2-butanone in yields above 90% (cf. Example 1B), which can be converted into diacetyl by alkaline or, preferably, acidic hydrolysis in a manner known per se in virtually quantitative yield. This is therefore a very advantageous overall process for the preparation of diacetyl from the readily available methyl ethyl ketone.
Workup
- customThese can be obtained very advantageously
Sources & evidence
- ORD record
- ord-c8deab39489a407b863091af1dbef2a3
- Source dataset
- uspto-grants-2001_11
- Patent number
- US06316676B1
Reaction notes
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