Dimethylamine, hydrochloride → HCID 18354909, compound

Participants

Reaction Steps

To a mixture of 4-[(2-carboxyindol-4-yl)-carbonyl]amino-3-methoxy-N-methyl-N-[4-methyl-2-[5-(4-methylpiperazin-1-yl)carbonylpent-1-yloxy]phenyl]benzamide (60 mg), N,N-dimethylamine hydrochloride (7.7 mg) and 1-hydroxybenzotriazole (14.5 mg) in N,N-dimethylformamide (3.0 ml) was added a solution of 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (20.6 mg) in N,N-dimethylformamide (1.0 ml) and the mixture was stirred at ambient temperature for 4 hours. The resulting mixture was diluted with ethyl acetate and the organic layer was washed successively with saturated aqueous sodium bicarbonate solution and brine. Drying, filtering and removal of solvents afforded 4-[(2-dimethylaminocarbonylindol-4-yl)-carbonyl]amino-3-methoxy-N-methyl-N-[4-methyl-2-[5-(4-methylpiperazin-1-yl)carbonylpent-1-yloxy]phenyl]benzamide (60 mg) as a yellow amorphous powder.

Provenance & Evidence