Triethylamine → HCID 18354823, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of N-(2-carboxy-4-methylphenyl)-3-methoxy-N-methyl-4-(2-methyl-1H-benzimidazol-4-yl)carbonylamino-benzamide (350 mg), diphenylphosphorylazide (224 mg) and triethylamine (82.5 mg) in dioxane (10 mg) was heated at 80° C. for 6 hours. After evaporation, the residual oil was subjected to silica gel column and the column was eluted with 5% methanol in chloroform. Object fractions were collected and evaporated in vacuo and the residue was solidified from chloroform to give N-(2-amino-4-methylphenyl)-3-methoxy-N-methyl-4-(2-methyl-1-H-benzimidazol-4-yl)carbonylamino-benzamide (280 mg).

Provenance & Evidence