4-Hydroxybenzaldehyde → HCID 54244580, compound

Participants

Reaction Steps

The application gives the manufacture of styryl glycidyl ether by first synthesizing 4-(2,3-epoxypropoxy)benzaldehyde from 4-hydroxy benzaldehyde and epichlorohydrin in the presence of NaOH, tetra-n-butyl ammonium iodide and dimethylsulfoxide. 4-(2,3-epoxypropoxy)benzaldehyde was then added to a dry tetrahydrofuran solution (0° C., argon atmosphere) containing suspended methyl-triphosphonium bromide, catalytic amounts of 18-crown-6-ether and potassium t-butoxide. From this mixture styryl glycidyl ether was then obtained in a yield of 70%.

Provenance & Evidence