Sodium Hydroxide → (2S,3R,4S,5R,6R)-2-[(2R,3S,4S,5R)-4,5-dihydroxy-2,5-bis(hydroxymethyl)oxolan-3-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol;hydrate
Reaction equation
[OH-:1].[Na+].[OH:3][CH:4]1[O:23][C@H:22]([CH2:24][OH:25])[C@@H:9]([O:10][C@@H:11]2[O:19][C@H:18]([CH2:20][OH:21])[C@H:16]([OH:17])[C@H:14]([OH:15])[C@H:12]2[OH:13])[C@H:7]([OH:8])[C@H:5]1[OH:6]>>[CH2:20]([OH:21])[C@H:18]1[O:19][C@@H:11]([O:10][C@H:9]2[C@H:7]([OH:8])[C@@:4]([OH:3])([CH2:5][OH:6])[O:23][C@@H:22]2[CH2:24][OH:25])[C@H:12]([OH:13])[C@@H:14]([OH:15])[C@H:16]1[OH:17].[OH2:1]Participants
Conditions
- Temperature
- 70 °C
Procedure
Sodium hydroxide is added to a 10% aqueous solution of commercially available lactose. followed by mixing, and thereafter the mixed solution was heated at 70° C. for 30 minutes and cooled. The cooled solution was purified by an ion-exchange resin, concentrated, cooled and crystallized and the unreacted lactose is removed to give an aqueous solution of lactulose in which the solid content is about 68% (where the solid contains about 79% of lactulose). This aqueous solution is passed through a column filled with a strongly acidic ion-exchange resin and a fraction containing lactulose is collected and concentrated to give an aqueous solution of pure lactulose containing about 68% of solid (where the solid contains about 86% of lactulose). This is the method disclosed in JP 3-169888 A.
Workup
- additionby mixing
- temperaturecooled
- customThe cooled solution was purified by an ion-exchange resin
- concentrationconcentrated
- temperaturecooled
- customcrystallized
- customthe unreacted lactose is removed
Sources & evidence
- ORD record
- ord-d130bc84710342b38a7c67064366910e
- Source dataset
- uspto-grants-2001_11
- Patent number
- US06319895B1
Reaction notes
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