反应详情

温度

70 °C

Sodium hydroxide is added to a 10% aqueous solution of commercially available lactose. followed by mixing, and thereafter the mixed solution was heated at 70° C. for 30 minutes and cooled. The cooled solution was purified by an ion-exchange resin, concentrated, cooled and crystallized and the unreacted lactose is removed to give an aqueous solution of lactulose in which the solid content is about 68% (where the solid contains about 79% of lactulose). This aqueous solution is passed through a column filled with a strongly acidic ion-exchange resin and a fraction containing lactulose is collected and concentrated to give an aqueous solution of pure lactulose containing about 68% of solid (where the solid contains about 86% of lactulose). This is the method disclosed in JP 3-169888 A.

1. additionby mixing
2. temperaturecooled
3. customThe cooled solution was purified by an ion-exchange resin
4. concentrationconcentrated
5. temperaturecooled
6. customcrystallized
7. customthe unreacted lactose is removed