Hydrochloric Acid → HCID 18352683, compound

Participants

Reaction Steps

3-(1-Acetylpiperidin-4-yl)-1-(4-acetyl-2,3,4,5-tetrahydro-1,4-benzoxazepin-7-yl)-1-propanone (1.5 g) obtained in Example 1 was dissolved in 30 ml of conc. hydrochloric acid, and the mixture was stirred for 16 hours under reflux. Excess volume of the conc. hydrochloric acid was distilled off under reduced pressure and ethanol was added to the residue. The resultant crystals were collected by filtration, and washed with ethanol. The crystals were dried under reduced pressure to give 1.4 g of the title compound as colorless scaly crystals, m.p. >300° C.

Provenance & Evidence